In vitroresistance to interferon of hepatitis B virus with precore mutation

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Precore Codon 28 Stop Mutation in Hepatitis B Virus from Patients with Hepatocellular Carcinoma

OBJECTIVES Hepatitis B virus (HBV) with a stop mutation at precore codon 28 (TGG-->TAG, tryptophan-->stop) was investigated to clarify if such a mutant virus might play a role in hepatocarcinogenesis. METHODS A total of 73 patients with HBV-related hepatocellular carcinoma were included in this study. Polymerase chain reaction (PCR) was performed in DNA samples extracted from 73 sera to ampli...

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Mechanism of suppression of hepatitis B virus precore RNA transcription by a frequent double mutation.

A double mutation which converts nucleotide 1765 from A to T and nucleotide 1767 from G to A is frequently found in the hepatitis B virus (HBV) genome isolated from HBV patients with chronic hepatitis symptoms. This double mutation is located in the core promoter that controls the transcription of the precore RNA and the core RNA. In addition, this double mutation also resides in the X protein ...

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Precore-mediated inhibition of hepatitis B virus progeny DNA synthesis.

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Mutations in the Basal Core Promoter and Precore/Core Regions of Hepatitis B Virus in Patients Co-Infected With Human Immunodeficiency Virus

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ژورنال

عنوان ژورنال: World Journal of Gastroenterology

سال: 2005

ISSN: 1007-9327

DOI: 10.3748/wjg.v11.i5.649